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A Study Looking at How Insulin Icodec is Taken up in the Blood When Administered in Different Injection Sites in People With Type 2 Diabetes Intervention 1 Not provided Anticipated Start Date Not provided Actual Start Date 2020-10-01 Anticipated Date of Last Follow-up 2023-01-19 Estimated Primary Completion Date Not provided Estimated Completion Date Not provided Actual Primary Completion Date 2021-09-27 Actual Completion Date 2021-09-27 Age Cohort Genders Accepts pregnant individuals Unspecified Accepts lactating individuals Unspecified Accepts healthy individuals No Inclusion Criteria: * Male or female * Aged 18-69 years (both inclusive) at the time of signing informed consent * Body mass index between 18.5 and 38.0 kg/m\^2 (both inclusive) * Diagnosed with type 2 diabetes mellitus above or equal to 180 days prior to the day of screening * HbA1c (glycated haemoglobin) below or equal to 9.0 percentage at screening * Current daily basal insulin treatment of 0.2-1.0 (I)U/kg/day (both inclusive) with or without any of the following anti-diabetic drugs/regimens with stable doses above or equal to 90 days prior to the day of screening: * Any metformin formulation * Other oral antidiabetic drugs: DPP-4 inhibitors / SGLT2 inhibitors / Oral combination products (for the allowed individual oral antidiabetic drugs) * Oral or injectable GLP-1 (glucagon-like pept Not provided Interventional (clinical trial) 25 Randomized Cross-over assignment Not provided Open label Not provided Treatment NCT04582435 Phase I Completed Novo Nordisk A/S The aim of the study is to improve clinical outcomes for patients with type 2 diabetes by limiting the burden associated with insulin treatment

The interaction of ox-LDL with CD36 triggers a signaling cascade that is necessary for ox-LDL uptake and foam cell formation and that alters cytoskeletal dynamics and inhibits migration, thus contributing to the trapping of foam cells within the atherosclerotic plaque [59]

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Semaglutide participants experienced higher rates of gallstones and cholecystitis compared to placebo, but this likely reflects the weight loss itself rather than direct medication toxicity

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